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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; Wilson, Peter W F; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G; Jackson, Anne U; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Christopher; Prins, Bram Peter; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Thériault, Sébastien; Verweij, Niek; Willems, Sara M; Zhao, Jing-Hua; Amouyel, Philippe; Connell, John; de Mutsert, Renée.
Afiliación
  • Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Warren HR; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Mosen-Ansorena D; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Mifsud B; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
  • Pazoki R; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Gao H; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Ntritsos G; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Dimou N; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Cabrera CP; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
  • Karaman I; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Ng FL; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Evangelou M; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Witkowska K; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
  • Tzanis E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Hellwege JN; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Giri A; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Velez Edwards DR; Department of Mathematics, Imperial College London, London, UK.
  • Sun YV; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Cho K; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Gaziano JM; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Wilson PWF; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA.
  • Tsao PS; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA.
  • Kovesdy CP; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
  • Esko T; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
  • Mägi R; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Milani L; Division of Aging, Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Almgren P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Boutin T; Division of Aging, Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Debette S; Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
  • Ding J; VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Giulianini F; Nephrology Section, Memphis VA Medical Center and University of Tennessee Health Science Center, Memphis, TN, USA.
  • Holliday EG; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Jackson AU; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Li-Gao R; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Lin WY; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Luan J; Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
  • Mangino M; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
  • Oldmeadow C; Department of Neurology, Bordeaux University Hospital, Bordeaux, France.
  • Prins BP; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France.
  • Qian Y; Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
  • Sargurupremraj M; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Shah N; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
  • Surendran P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Thériault S; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Verweij N; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Zhao JH; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
  • Amouyel P; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
  • Connell J; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
  • de Mutsert R; Wellcome Trust Sanger Institute, Hinxton, UK.
Nat Genet ; 50(10): 1412-1425, 2018 10.
Article en En | MEDLINE | ID: mdl-30224653
ABSTRACT
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Sitios de Carácter Cuantitativo Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Sitios de Carácter Cuantitativo Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido