Gliosarcoma arising from oligodendroglioma (Oligosarcoma): A case report with genetic analyses.
Pathol Int
; 68(10): 567-573, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30246385
ABSTRACT
Gliosarcomas are a type of bimorphic tumor composed of glial and sarcomatous elements, and are considered to be a variant of glioblastoma, WHO grade IV. To date, only rare cases of gliosarcoma with oligodendroglial components (oligosarcoma) have been reported. We report a case of oligosarcoma consisting of gliosarcoma arising from recurrent oligodendroglioma. A 53-year-old man, who had undergone a gross total resection of oligodendroglioma (WHO grade II) 11 years earlier, presented with a local tumor recurrence. The patient underwent a second gross total resection, whereupon a histopathological examination further revealed residual features of classical oligodendroglioma, and newly-developed sarcomatous characteristics. Both the primary and recurrent tumors showed 1p/19q co-deletion and mutation of the isocitrate dehydrogenase 1 (IDH1) gene, consistent with being oligodendroglial in nature. Loss of heterozygosity (LOH) of chromosome 1p/19q and IDH1 mutation have seldom been analyzed in previous reports of oligosarcomas. We report a rare case study supported by the results of genetic analyses. Our analyses have revealed that the sarcomatous component represents a metaplastic change occurring in the oligodendroglial element.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oligodendroglioma
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Neoplasias Encefálicas
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Gliosarcoma
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Recurrencia Local de Neoplasia
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Neoplasias Primarias Múltiples
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Pathol Int
Asunto de la revista:
PATOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón