Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.

Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M; Smith, Lyndsay; Cameron, Michael D; Ruiz, Claudia; Fields, Gregg B; Roush, William R

Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M; Smith, Lyndsay; Cameron, Michael D; Ruiz, Claudia; Fields, Gregg B; Roush, William R.

Afiliación

Fuerst R; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States; Institute of Organic Chemistry, Graz University of Technology, 8010 Graz, Austria.
Yong Choi J; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States; Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, New York 11367, United States.
Knapinska AM; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Smith L; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Cameron MD; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States.
Ruiz C; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States.
Fields GB; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Roush WR; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States. Electronic address: roush@scripps.edu.

Bioorg Med Chem ; 26(18): 4984-4995, 2018 10 01.

Article en En | MEDLINE | ID: mdl-30249495

Asunto(s)

Metaloproteinasa 13 de la Matriz/efectos de los fármacos; Inhibidores de la Metaloproteinasa de la Matriz/química; Inhibidores de la Metaloproteinasa de la Matriz/farmacología; Animales; Inhibidores Enzimáticos del Citocromo P-450/farmacología; Semivida; Humanos; Concentración 50 Inhibidora; Cinética; Inhibidores de la Metaloproteinasa de la Matriz/farmacocinética; Ratones; Microsomas Hepáticos/metabolismo; Modelos Animales; Ratas; Solubilidad; Relación Estructura-Actividad

Palabras clave

In vitro and in vivo pharmacokinetics; Matrix metalloproteinase 13; Microsomal stability; Permeability; Solubility; Structure-activity relationship; Structure-property relationship

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metaloproteinasa 13 de la Matriz / Inhibidores de la Metaloproteinasa de la Matriz Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Austria

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