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N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Hoveyda, Hamid R; Fraser, Graeme L; Zoute, Ludivine; Dutheuil, Guillaume; Schils, Didier; Brantis, Cyrille; Lapin, Alexey; Parcq, Julien; Guitard, Sandra; Lenoir, François; Bousmaqui, Mohamed El; Rorive, Sarah; Hospied, Sandrine; Blanc, Sébastien; Bernard, Jérôme; Ooms, Frédéric; McNelis, Joanne C; Olefsky, Jerrold M.
Afiliación
  • Hoveyda HR; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium. Electronic address: hamidhoveyda@hotmail.com.
  • Fraser GL; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Zoute L; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Dutheuil G; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Schils D; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Brantis C; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Lapin A; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Parcq J; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Guitard S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Lenoir F; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Bousmaqui ME; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Rorive S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Hospied S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Blanc S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Bernard J; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • Ooms F; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium.
  • McNelis JC; University of California, Department of Medicine, San Diego, CA 92161, USA.
  • Olefsky JM; University of California, Department of Medicine, San Diego, CA 92161, USA.
Bioorg Med Chem ; 26(18): 5169-5180, 2018 10 01.
Article en En | MEDLINE | ID: mdl-30253886
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiazoles / Receptores de Superficie Celular / Diabetes Mellitus Experimental / Modelos Animales de Enfermedad / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiazoles / Receptores de Superficie Celular / Diabetes Mellitus Experimental / Modelos Animales de Enfermedad / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article