Statistical Detection of Relatives Typed with Disjoint Forensic and Biomedical Loci.
Cell
; 175(3): 848-858.e6, 2018 10 18.
Article
en En
| MEDLINE
| ID: mdl-30318150
ABSTRACT
In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonoverlapping genetic markers. Considering data on individuals genotyped with both microsatellites used in forensic applications and genome-wide SNPs, we find that â¼30%-32% of parent-offspring pairs and â¼35%-36% of sib pairs can be identified from the SNPs of one member of the pair and the microsatellites of the other. The method suggests the possibility of performing familial searches of microsatellite databases using query SNP profiles, or vice versa. It also reveals that privacy concerns arising from computations across multiple databases that share no genetic markers in common entail risks, not only for database entrants, but for their close relatives as well.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Familia
/
Polimorfismo de Nucleótido Simple
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Genética Forense
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Técnicas de Genotipaje
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Genética de Población
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Cell
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos