Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity.

Sfyri, Pagona Panagiota; Yuldasheva, Nadira Y; Tzimou, Anastasia; Giallourou, Natasa; Crispi, Vassili; Aburima, Ahmed; Beltran-Alvarez, Pedro; Patel, Ketan; Mougios, Vassilis; Swann, Jonathan R; Kearney, Mark T; Matsakas, Antonios

Sfyri, Pagona Panagiota; Yuldasheva, Nadira Y; Tzimou, Anastasia; Giallourou, Natasa; Crispi, Vassili; Aburima, Ahmed; Beltran-Alvarez, Pedro; Patel, Ketan; Mougios, Vassilis; Swann, Jonathan R; Kearney, Mark T; Matsakas, Antonios.

Afiliación

Sfyri PP; Molecular Physiology Laboratory, Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, United Kingdom.
Yuldasheva NY; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom.
Tzimou A; Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sports Science at Thessaloniki, Aristotle University of Thessaloniki, Greece.
Giallourou N; Department of Surgery and Cancer, Division of Computational and Systems Medicine, Imperial College London, United Kingdom.
Crispi V; Molecular Physiology Laboratory, Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, United Kingdom.
Aburima A; Molecular Physiology Laboratory, Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, United Kingdom.
Beltran-Alvarez P; School of Life Sciences, University of Hull, United Kingdom.
Patel K; School of Biological Sciences, University of Reading, United Kingdom.
Mougios V; Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sports Science at Thessaloniki, Aristotle University of Thessaloniki, Greece.
Swann JR; Department of Surgery and Cancer, Division of Computational and Systems Medicine, Imperial College London, United Kingdom.
Kearney MT; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom.
Matsakas A; Molecular Physiology Laboratory, Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, United Kingdom. Electronic address: Antonios.Matsakas@hyms.ac.uk.

Free Radic Biol Med ; 129: 504-519, 2018 12.

Article en En | MEDLINE | ID: mdl-30342191

Asunto(s)

Aterosclerosis/tratamiento farmacológico; Hiperlipidemias/tratamiento farmacológico; Hipolipemiantes/farmacología; Metabolismo de los Lípidos/efectos de los fármacos; Músculo Esquelético/efectos de los fármacos; NADPH Oxidasa 2/genética; Animales; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Aterosclerosis/etiología; Aterosclerosis/genética; Aterosclerosis/patología; Dieta Occidental/efectos adversos; Modelos Animales de Enfermedad; Inhibidores Enzimáticos/farmacología; Regulación de la Expresión Génica; Hiperlipidemias/etiología; Hiperlipidemias/genética; Hiperlipidemias/patología; Metabolismo de los Lípidos/genética; Hígado/efectos de los fármacos; Hígado/enzimología; Hígado/patología; Masculino; Metaboloma/efectos de los fármacos; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Músculo Esquelético/enzimología; Músculo Esquelético/patología; NADPH Oxidasa 2/antagonistas & inhibidores; NADPH Oxidasa 2/metabolismo; Obesidad; Oxidación-Reducción; Estrés Oxidativo/efectos de los fármacos; Péptidos/farmacología; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal

Palabras clave

Atherosclerosis; NADPH oxidase; Oxidative stress; Skeletal muscle; Western-type diet

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Aterosclerosis / Metabolismo de los Lípidos / NADPH Oxidasa 2 / Hiperlipidemias / Hipolipemiantes Tipo de estudio: Etiology_studies Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido

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