Efficacy of panitumumab in older patients with metastatic colorectal cancer: a retrospective analysis using the database of the Hellenic Oncology Research Group (HORG).
J Geriatr Oncol
; 10(1): 143-148, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30366852
ABSTRACT
BACKGROUND:
Although colorectal cancer (CRC) is a disease of the older patients, older patients are under-represented from randomized trials. Herein we conducted a retrospective analysis for the effect of panitumumab in the management of older patients (≥65â¯years) patients with metastatic CRC (mCRC) in the Hellenic Oncology Research Group's (HORG) database.METHODS:
Τhe efficacy of panitumumab-based chemotherapy as front-line treatment in older patients with mCRC was assessed.RESULTS:
In total, 110 older patients with KRAS exon 2 wild type tumors were treated with chemotherapy plus panitumumab. The median age was 74â¯years; 69.9% of the patients were male, with left-sided primary tumors (78.2%), ECOG Performance Status 0-1 (95.4%) and median number of metastatic sites 2. Sixty-two (Overall Response Rate-ORR 56.4%; 95% CI 48.8%-68.1%) achieved an objective response, while 21 (19.1%) had stable disease. Median Progression free survival (PFS) was 9.4â¯months (95% CI 7.8-11.0â¯months) and median Overall survival (OS) 23.0â¯months (95% CI 20.6-25.3â¯months). Additionally, a statistically significant difference in ORR (62.7% vs. 33.3%; pâ¯=â¯.014), median PFS (12.9 vs. 5.7â¯months; pâ¯=â¯.001) and median OS (31.6 vs. 16.7â¯months; pâ¯<â¯.001) was observed in patients with left-sided compared to right-sided primary tumor. There was no treatment-related death. Grade 3-4 toxicities were neutropenia (8.9%) and diarrhea (14.5%) whereas skin rash grade 2 or 3 was recorded in 41.1% and 10.7%, respectively.CONCLUSIONS:
The results of this retrospective study provide the evidence that combination chemotherapy plus panitumumab is active and well tolerated in older patients with mCRC.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Antineoplásicos Inmunológicos
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Panitumumab
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Geriatr Oncol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Grecia