Does T Cell Activation Require a Quorum of Lymphocytes?
J Immunol
; 201(10): 2855-2861, 2018 11 15.
Article
en En
| MEDLINE
| ID: mdl-30397169
ABSTRACT
Recent reports suggest a quorum of T cells is required to activate T lymphocytes and that this requirement may help explain why scarce lymphocytes, specific for peripheral self-antigen, are rarely activated by Ag. This proposal runs counter to the commonly held framework that the Ag-dependent, but CD4 T lymphocyte-independent, activation of CD8 T lymphocytes, and the activation of CD4 T lymphocytes themselves, can occur when a single CD8 or CD4 T lymphocyte encounters Ag under appropriately dangerous circumstances. We argue that a review of older literature often ignored, as well as of contemporary studies, supports the quorum concept and is difficult to reconcile with the Danger Model.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá