Pathologies of matrix metalloproteinase-2 underactivity: a perspective on a neglected condition 1.
Can J Physiol Pharmacol
; 97(6): 486-492, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30457883
ABSTRACT
A member of the matrix metalloproteinase family, matrix metalloproteinase-2 (MMP-2, gelatinase A), has been extensively studied for its role in both normal physiology and pathological processes. Whereas most research efforts in recent years have investigated the pathologies associated with MMP-2 overactivity, the pathological mechanisms elicited by MMP-2 underactivity are less well understood. Here, we distinguish between 2 states and describe their causes (i) MMP-2 deficiency (complete loss of MMP-2 activity) and (ii) MMP-2 insufficiency (defined as MMP-2 activity below baseline levels). Further, we review the biology of MMP-2, summarizing the current literature on MMP-2 underactivity in both mice and humans, and describe research being conducted by our lab towards improving our understanding of the pathological mechanisms elicited by MMP-2 deficiency/insufficiency. We think that this research could stimulate the discovery of new therapeutic approaches for managing pathologies associated with MMP-2 underactivity. Moreover, similar concepts could apply to other members of the matrix metalloproteinase family.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad
/
Metaloproteinasa 2 de la Matriz
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Can J Physiol Pharmacol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Canadá