Heterogeneous mutational profile and prognosis conferred by TP53 mutations in appendiceal mucinous neoplasms.

Zhu, Xiaoqin; Salhab, Mohammed; Tomaszewicz, Keith; Meng, Xiuling; Mathew, Carol; Bathini, Venu; Switzer, Bradley; Walter, Otto; Cosar, Ediz F; Wang, Xiaofei; Lambert, Laura A; Hutchinson, Lloyd M

Zhu, Xiaoqin; Salhab, Mohammed; Tomaszewicz, Keith; Meng, Xiuling; Mathew, Carol; Bathini, Venu; Switzer, Bradley; Walter, Otto; Cosar, Ediz F; Wang, Xiaofei; Lambert, Laura A; Hutchinson, Lloyd M.

Afiliación

Zhu X; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Salhab M; Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Tomaszewicz K; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Meng X; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Mathew C; Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Bathini V; Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Switzer B; Division of Hematology/Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Walter O; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA; Ruffolo, Hooper & Associates, M.D., P.A., Tampa, FL 32891, USA.
Cosar EF; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Wang X; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA.
Lambert LA; Division of Surgical Oncology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA; Huntsman Cancer Institute, University of Utah, Section of Surgical Oncology, Salt Lake City, UT 84112, USA. Electronic address: Laura.Lambert@hci.utah.edu.
Hutchinson LM; Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA. Electronic address: Lloyd.Hutchinson@umassmemorial.org.

Hum Pathol ; 85: 260-269, 2019 03.

Article en En | MEDLINE | ID: mdl-30458197

Asunto(s)

Adenocarcinoma Mucinoso/genética; Neoplasias del Apéndice/genética; Mutación; Proteína p53 Supresora de Tumor/genética; Adenocarcinoma Mucinoso/mortalidad; Adenocarcinoma Mucinoso/patología; Adulto; Anciano; Neoplasias del Apéndice/mortalidad; Neoplasias del Apéndice/patología; Biomarcadores de Tumor; Fosfatidilinositol 3-Quinasa Clase I/genética; Análisis Mutacional de ADN; Femenino; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Masculino; Persona de Mediana Edad; Clasificación del Tumor; Estadificación de Neoplasias; Pronóstico; Proteínas Proto-Oncogénicas p21(ras)/genética; Tasa de Supervivencia; beta Catenina/genética

Palabras clave

AJCC eighth edition; Appendiceal mucinous neoplasms; Mutational profile; Next-generation sequencing; TP53 mutation; p53 immunohistochemistry prognosis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Proteína p53 Supresora de Tumor / Adenocarcinoma Mucinoso / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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