Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.

Barkeer, Srikanth; Chugh, Seema; Karmakar, Saswati; Kaushik, Garima; Rauth, Sanchita; Rachagani, Satyanarayana; Batra, Surinder K; Ponnusamy, Moorthy P

Barkeer, Srikanth; Chugh, Seema; Karmakar, Saswati; Kaushik, Garima; Rauth, Sanchita; Rachagani, Satyanarayana; Batra, Surinder K; Ponnusamy, Moorthy P.

Afiliación

Barkeer S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Chugh S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Karmakar S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Kaushik G; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Rauth S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Rachagani S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
Ponnusamy MP; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

BMC Cancer ; 18(1): 1157, 2018 Nov 22.

Article en En | MEDLINE | ID: mdl-30466404

Asunto(s)

Autorrenovación de las Células/genética; N-Acetilgalactosaminiltransferasas/genética; N-Acetilglucosaminiltransferasas/genética; Células Madre Neoplásicas/metabolismo; Neoplasias Pancreáticas/genética; Biomarcadores de Tumor; Línea Celular Tumoral; Movimiento Celular/genética; Proliferación Celular/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica; Técnicas de Silenciamiento del Gen; Glicosilación; Humanos; Receptores de Hialuranos/metabolismo; Modelos Biológicos; N-Acetilgalactosaminiltransferasas/metabolismo; N-Acetilglucosaminiltransferasas/metabolismo; Estadificación de Neoplasias; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patología; Fenotipo; Polipéptido N-Acetilgalactosaminiltransferasa

Palabras clave

B3GNT3; CD44v6; GALNT3; Glycosylation; Pancreatic cancer stem cells; Tunicamycin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Células Madre Neoplásicas / N-Acetilglucosaminiltransferasas / N-Acetilgalactosaminiltransferasas / Autorrenovación de las Células Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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