O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5.

Wu, Nan; Jiang, Mingzuo; Han, Yuying; Liu, Haiming; Chu, Yi; Liu, Hao; Cao, Jiayi; Hou, Qiuqiu; Zhao, Yu; Xu, Bing; Xie, Xin

Wu, Nan; Jiang, Mingzuo; Han, Yuying; Liu, Haiming; Chu, Yi; Liu, Hao; Cao, Jiayi; Hou, Qiuqiu; Zhao, Yu; Xu, Bing; Xie, Xin.

Afiliación

Wu N; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Jiang M; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Han Y; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Liu H; College of Computer Science and Technology, Jilin University, Changchun, Jilin, China.
Chu Y; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Liu H; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Cao J; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Hou Q; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Zhao Y; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Xu B; Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiao tong University, Xi'an, Shaanxi, China.
Xie X; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.

J Cell Mol Med ; 23(2): 1354-1362, 2019 02.

Article en En | MEDLINE | ID: mdl-30484950

Asunto(s)

Biomarcadores de Tumor/metabolismo; Neoplasias Colorrectales/patología; ARN Helicasas DEAD-box/química; ARN Helicasas DEAD-box/metabolismo; Procesamiento Proteico-Postraduccional; Proteínas Proto-Oncogénicas c-akt/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; Animales; Apoptosis; Biomarcadores de Tumor/genética; Movimiento Celular; Proliferación Celular; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; ARN Helicasas DEAD-box/genética; Progresión de la Enfermedad; Regulación Neoplásica de la Expresión Génica; Glicosilación; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; N-Acetilglucosaminiltransferasas/metabolismo; Estabilidad Proteica; Proteínas Proto-Oncogénicas c-akt/genética; Serina-Treonina Quinasas TOR/genética; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

AKT; Colorectal cancer; DDX5; O-GlcNAcylation; mTOR

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Procesamiento Proteico-Postraduccional / Proteínas Proto-Oncogénicas c-akt / ARN Helicasas DEAD-box / Serina-Treonina Quinasas TOR Límite: Animals / Humans / Male Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: China

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