Oxidative NHC catalysis: direct activation of ß sp3 carbons of saturated acid chlorides.
Chem Commun (Camb)
; 55(3): 298-301, 2019 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-30506079
ABSTRACT
The first activation of saturated acid chlorides by oxidative N-heterocyclic carbene catalysis has been successfully utilized to synthesize enantio-enriched spirooxindole lactones and δ-lactones. The reaction involves the transformation of the ß sp3 carbon of saturated acid chlorides into an electrophilic carbon as a key step. The product was obtained in excellent yield and stereoselectivity.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article