Glioma exosomes mediate the expansion and function of myeloid-derived suppressor cells through microRNA-29a/Hbp1 and microRNA-92a/Prkar1a pathways.

Guo, Xiaofan; Qiu, Wei; Wang, Jian; Liu, Qinglin; Qian, Mingyu; Wang, Shaobo; Zhang, Zongpu; Gao, Xiao; Chen, Zihang; Guo, Qindong; Xu, Jianye; Xue, Hao; Li, Gang

Guo, Xiaofan; Qiu, Wei; Wang, Jian; Liu, Qinglin; Qian, Mingyu; Wang, Shaobo; Zhang, Zongpu; Gao, Xiao; Chen, Zihang; Guo, Qindong; Xu, Jianye; Xue, Hao; Li, Gang.

Afiliación

Guo X; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, People's Republic of China.
Qiu W; Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, People's Republic of China.
Wang J; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, People's Republic of China.
Liu Q; Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, People's Republic of China.
Qian M; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, People's Republic of China.
Wang S; Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, People's Republic of China.
Zhang Z; Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, People's Republic of China.
Gao X; Department of Biomedicine, University of Bergen, Bergen, Norway.
Chen Z; Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, People's Republic of China.
Guo Q; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, People's Republic of China.
Xu J; Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, People's Republic of China.
Xue H; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, People's Republic of China.
Li G; Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, People's Republic of China.

Int J Cancer ; 144(12): 3111-3126, 2019 06 15.

Article en En | MEDLINE | ID: mdl-30536597

Asunto(s)

Neoplasias Encefálicas/metabolismo; Subunidad RIalfa de la Proteína Quinasa Dependiente de AMP Cíclico/metabolismo; Exosomas/metabolismo; Glioblastoma/metabolismo; Proteínas del Grupo de Alta Movilidad/metabolismo; MicroARNs/metabolismo; Células Supresoras de Origen Mieloide/metabolismo; Animales; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/inmunología; Neoplasias Encefálicas/patología; Hipoxia de la Célula/fisiología; Línea Celular Tumoral; Subunidad RIalfa de la Proteína Quinasa Dependiente de AMP Cíclico/genética; Exosomas/genética; Exosomas/patología; Glioblastoma/inmunología; Glioblastoma/patología; Proteínas del Grupo de Alta Movilidad/genética; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; MicroARNs/genética; Células Supresoras de Origen Mieloide/inmunología; Células Supresoras de Origen Mieloide/patología; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Transducción de Señal

Palabras clave

MDSCs; exosome; glioma; hypoxia; miR-29a; miR-92a

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Proteínas del Grupo de Alta Movilidad / Glioblastoma / MicroARNs / Subunidad RIalfa de la Proteína Quinasa Dependiente de AMP Cíclico / Exosomas / Células Supresoras de Origen Mieloide Límite: Animals / Humans / Male Idioma: En Revista: Int J Cancer Año: 2019 Tipo del documento: Article

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