Presence of CD34+ in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patients.
In Vivo
; 33(1): 277-280, 2019.
Article
en En
| MEDLINE
| ID: mdl-30587636
ABSTRACT
BACKGROUND/AIM:
Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a "favorable" prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients. MATERIALS ANDMETHODS:
Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk.RESULTS:
CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281).CONCLUSION:
The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pronóstico
/
Síndromes Mielodisplásicos
/
Proteína p53 Supresora de Tumor
/
Antígenos CD34
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
In Vivo
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil