All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element.

Tamaki, Masanori; Tominaga, Tatsuya; Fujita, Yui; Koezuka, Yasuhiko; Ichien, Go; Murakami, Taichi; Kishi, Seiji; Yamamoto, Keiichi; Abe, Hideharu; Nagai, Kojiro; Doi, Toshio

Tamaki, Masanori; Tominaga, Tatsuya; Fujita, Yui; Koezuka, Yasuhiko; Ichien, Go; Murakami, Taichi; Kishi, Seiji; Yamamoto, Keiichi; Abe, Hideharu; Nagai, Kojiro; Doi, Toshio.

Afiliación

Tamaki M; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Tominaga T; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Fujita Y; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Koezuka Y; Hubit Genomix, Tokyo , Japan.
Ichien G; Hubit Genomix, Tokyo , Japan.
Murakami T; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Kishi S; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Yamamoto K; Fuso Pharmaceutical Industries, Osaka , Japan.
Abe H; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Nagai K; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Doi T; Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.

Am J Physiol Endocrinol Metab ; 316(3): E418-E431, 2019 03 01.

Article en En | MEDLINE | ID: mdl-30601699

Asunto(s)

Proteína Morfogenética Ósea 4/efectos de los fármacos; Colágeno Tipo IV/efectos de los fármacos; Nefropatías Diabéticas/metabolismo; Células Mesangiales/efectos de los fármacos; Tretinoina/farmacología; Animales; Proteína Morfogenética Ósea 4/genética; Proteína Morfogenética Ósea 4/metabolismo; Células Cultivadas; Colágeno Tipo IV/genética; Colágeno Tipo IV/metabolismo; Células Mesangiales/metabolismo; Ratones; Elementos de Respuesta; Receptor alfa de Ácido Retinoico/agonistas; Receptores X Retinoide/metabolismo; Proteína Smad1/efectos de los fármacos; Proteína Smad1/genética; Proteína Smad1/metabolismo

Palabras clave

all-trans retinoic acid; bone morphogenetic protein 4; diabetic nephropathy; mesangial matrix expansion; retinoic acid receptor-α

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tretinoina / Colágeno Tipo IV / Nefropatías Diabéticas / Células Mesangiales / Proteína Morfogenética Ósea 4 Límite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Japón

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