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AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth.
Patra, Krushna C; Weerasekara, Vajira K; Bardeesy, Nabeel.
Afiliación
  • Patra KC; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02113, USA.
  • Weerasekara VK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02113, USA.
  • Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02113, USA. Electronic address: bardeesy.nabeel@mgh.harvard.edu.
Cell Metab ; 29(2): 238-240, 2019 02 05.
Article en En | MEDLINE | ID: mdl-30612899
ABSTRACT
Cancer cells must adapt to metabolic stress during tumor progression. In this issue of Cell Metabolism, Eichner et al. (2019) report that lung cancer development in genetically engineered mice requires the energy sensor AMP-activated protein kinase (AMPK). Their findings suggest that AMPK-mediated induction of lysosomal function supports cancer cell fitness, particularly during the early stages of tumorigenesis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por AMP / Neoplasias Pulmonares Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por AMP / Neoplasias Pulmonares Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos