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Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
Boehm, Jeffrey; Davis, Roderick; Murar, Claudia E; Li, Tindy; McCleland, Brent; Dong, Shuping; Yan, Hongxing; Kerns, Jeffrey; Moody, Christopher J; Wilson, Anthony J; Graves, Alan P; Mentzer, Mary; Qi, Hongwei; Yonchuk, John; Kou, Jen-Pyng; Foley, Joseph; Sanchez, Yolanda; Podolin, Patricia L; Bolognese, Brian; Booth-Genthe, Catherine; Galop, Marc; Wolfe, Lawrence; Carr, Robin; Callahan, James F.
Afiliación
  • Boehm J; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA. Electronic address: jeffrey.c.boehm@gsk.com.
  • Davis R; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Murar CE; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Li T; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • McCleland B; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Dong S; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Yan H; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Kerns J; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Moody CJ; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
  • Wilson AJ; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
  • Graves AP; Platform Technology and Science, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Mentzer M; Platform Technology and Science, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Qi H; Platform Technology and Science, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Yonchuk J; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Kou JP; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Foley J; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Sanchez Y; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Podolin PL; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Bolognese B; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Booth-Genthe C; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Galop M; Platform Technology and Science, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Wolfe L; Platform Technology and Science, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Carr R; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
  • Callahan JF; Respiratory Stress and Repair DPU, GlaxoSmithKline, Upper Providence, PA 19426, USA.
Bioorg Med Chem ; 27(4): 579-588, 2019 02 15.
Article en En | MEDLINE | ID: mdl-30626555
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Isotiocianatos / Ciclobutanos / Factor 2 Relacionado con NF-E2 / Descubrimiento de Drogas / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Isotiocianatos / Ciclobutanos / Factor 2 Relacionado con NF-E2 / Descubrimiento de Drogas / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article