Conversion of Quinazoline Modulators from Inhibitors to Activators of ß-Glucocerebrosidase.

Zheng, Jianbin; Jeon, Sohee; Jiang, Weilan; Burbulla, Lena F; Ysselstein, Daniel; Oevel, Kristine; Krainc, Dimitri; Silverman, Richard B

Zheng, Jianbin; Jeon, Sohee; Jiang, Weilan; Burbulla, Lena F; Ysselstein, Daniel; Oevel, Kristine; Krainc, Dimitri; Silverman, Richard B.

Afiliación

Zheng J; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics , Northwestern University , Evanston , Illinois 60208 , United States.
Jeon S; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Jiang W; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Burbulla LF; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Ysselstein D; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Oevel K; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Krainc D; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.
Silverman RB; Department of Neurology , Northwestern University Feinberg School of Medicine , Chicago , Illinois 60611 , United States.

J Med Chem ; 62(3): 1218-1230, 2019 02 14.

Article en En | MEDLINE | ID: mdl-30645117

Asunto(s)

Activadores de Enzimas/farmacología; Inhibidores Enzimáticos/farmacología; Glucosilceramidasa/antagonistas & inhibidores; Quinazolinas/farmacología; Neuronas Dopaminérgicas/efectos de los fármacos; Activadores de Enzimas/química; Activadores de Enzimas/uso terapéutico; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/uso terapéutico; Enfermedad de Gaucher/tratamiento farmacológico; Humanos; Metilación; Enfermedad de Parkinson/tratamiento farmacológico; Enfermedad de Parkinson/patología; Quinazolinas/química; Quinazolinas/uso terapéutico; Relación Estructura-Actividad

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Activadores de Enzimas / Inhibidores Enzimáticos / Glucosilceramidasa Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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