From Target Identification to Drug Development in Space: Using the Microgravity Assist.
Curr Drug Discov Technol
; 17(1): 45-56, 2020.
Article
en En
| MEDLINE
| ID: mdl-30648510
ABSTRACT
The unique nature of microgravity encountered in space provides an opportunity for drug discovery and development that cannot be replicated on Earth. From the production of superior protein crystals to the identification and validation of new drug targets to microarray analyses of transcripts attenuated by microgravity, there are numerous examples which demonstrate the benefit of exploiting the space environment. Moreover, studies conducted on Space Shuttle missions, the International Space Station and other craft have had a direct benefit for drug development programmes such as those directed against reducing bone and muscle loss or increasing bone formation. This review will highlight advances made in both drug discovery and development and offer some future insight into how drug discovery and associated technologies may be further advanced using the microgravity assist.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vuelo Espacial
/
Ingravidez
/
Descubrimiento de Drogas
/
Desarrollo de Medicamentos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Drug Discov Technol
Asunto de la revista:
FARMACOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido