CAPAM: The mRNA Cap Adenosine N6-Methyltransferase.

Cowling, Victoria H

Cowling, Victoria H.

Afiliación

Cowling VH; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address: v.h.cowling@dundee.ac.uk.

Trends Biochem Sci ; 44(3): 183-185, 2019 03.

Article en En | MEDLINE | ID: mdl-30679132

ABSTRACT

ABSTRACT

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

Asunto(s)

Metiltransferasas/metabolismo; Caperuzas de ARN/metabolismo; ARN Mensajero/metabolismo; Adenosina/metabolismo; Animales; Humanos; Metilación

Palabras clave

CAPAM; Pcif1; gene expression; m6Am; mRNA cap; mRNA cap methyltransferase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Caperuzas de ARN / ARN Mensajero / Metiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 2019 Tipo del documento: Article

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