Mechanisms of hypertension in autoimmune rheumatic diseases.
Br J Pharmacol
; 176(12): 1897-1913, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30714094
ABSTRACT
Patients with autoimmune rheumatic diseases including rheumatoid arthritis and systemic lupus erythematosus have an increased prevalence of hypertension. There is now a large body of evidence showing that the immune system is a key mediator in both human primary hypertension and experimental models. Many of the proposed immunological mechanisms leading to primary hypertension are paralleled in autoimmune rheumatic disorders. Therefore, examining the link between autoimmunity and hypertension can be informative for understanding primary hypertension. This review examines the prevalent hypertension, the immune mediators that contribute to the prevalent hypertension and their impact on renal function and how the risk of hypertension is potentially influenced by common hormonal changes that are associated with autoimmune rheumatic diseases. LINKED ARTICLES This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http//onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Enfermedades Reumáticas
/
Hipertensión
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Br J Pharmacol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos