Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals.
J Infect Dis
; 219(11): 1749-1754, 2019 05 05.
Article
en En
| MEDLINE
| ID: mdl-30715363
ABSTRACT
Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas
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Infecciones por VIH
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VIH-1
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VIH-2
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Reacciones Cruzadas
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Productos del Gen env del Virus de la Inmunodeficiencia Humana
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Citotoxicidad Celular Dependiente de Anticuerpos
Límite:
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2019
Tipo del documento:
Article
País de afiliación:
Dinamarca