Cost-effectiveness of elagolix versus leuprolide acetate for treating moderate-to-severe endometriosis pain in the USA.
J Comp Eff Res
; 8(5): 337-355, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30724096
ABSTRACT
AIM:
To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain.METHODS:
A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Model inputs were extracted from Phase III clinical trials and published literature.RESULTS:
Compared with leuprolide acetate, elagolix generated positive net monetary benefit (NMB) assuming a payer's willingness-to-pay threshold of US$100,000 per quality-adjusted life year over a 1-year time horizon US$5660 for elagolix 150 mg and US$6443 for elagolix 200 mg. The 2-year NMBs were also positive.CONCLUSION:
Elagolix was cost effective versus leuprolide acetate in the management of moderate to severe endometriosis pain over 1- and 2-year time horizons. Results were robust in sensitivity analyses.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Leuprolida
/
Endometriosis
/
Fármacos para la Fertilidad Femenina
/
Hidrocarburos Fluorados
Tipo de estudio:
Etiology_studies
/
Health_economic_evaluation
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Comp Eff Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos