Structural characterization of the &#945;-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.

Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W; Zhang, Bohong; Concino, Michael F; Meiyappan, Muthuraman

Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.

Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W; Zhang, Bohong; Concino, Michael F; Meiyappan, Muthuraman.

Afiliación

Birrane G; Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA 02215, United States.
Dassier AL; Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA 02215, United States.
Romashko A; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Lundberg D; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Holmes K; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Cottle T; Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA 02215, United States.
Norton AW; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Zhang B; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Concino MF; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States.
Meiyappan M; Discovery Therapeutics, Research-US, Takeda Pharmaceutical Company Limited, 125 Binney St., Cambridge, MA 02142, United States. Electronic address: muthu.meiyappan@takeda.com.

J Struct Biol ; 205(3): 65-71, 2019 03 01.

Article en En | MEDLINE | ID: mdl-30802506

Asunto(s)

Acetilglucosamina/química; Acetilglucosaminidasa/química; Acetilglucosamina/metabolismo; Acetilglucosaminidasa/genética; Acetilglucosaminidasa/metabolismo; Secuencias de Aminoácidos; Dominio Catalítico; Línea Celular Tumoral; Clonación Molecular; Cristalografía por Rayos X; Fibroblastos/citología; Fibroblastos/metabolismo; Expresión Génica; Vectores Genéticos/química; Vectores Genéticos/metabolismo; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Modelos Moleculares; Mucopolisacaridosis III/enzimología; Mucopolisacaridosis III/genética; Mucopolisacaridosis III/patología; Mutación; Unión Proteica; Conformación Proteica en Hélice alfa; Conformación Proteica en Lámina beta; Dominios y Motivos de Interacción de Proteínas; Multimerización de Proteína; Estructura Terciaria de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Electricidad Estática; Homología Estructural de Proteína; Especificidad por Sustrato

Palabras clave

Crystal structure; Heparan sulfate; Mucopolysaccharidosis III B; Sanfilippo syndrome B

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetilglucosamina / Acetilglucosaminidasa Tipo de estudio: Etiology_studies Idioma: En Revista: J Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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