Expression of YY1 in Wilms tumors with favorable histology is a risk factor for adverse outcomes.
Future Oncol
; 15(11): 1231-1241, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30810052
ABSTRACT
AIM:
To investigate the role of the transcription factor YY1 in Wilms tumor (WT). PATIENTS &METHODS:
We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical and protein expression was determined by digital pathology. RESULTS &CONCLUSION:
YY1 significantly increased in WT patients. In addition, an increase in YY1 expression had a greater risk of adverse outcomes in WT patients with favorable histology. YY1 expression was higher in the blastemal component of tumors, and high nuclear expression positively correlated with metastasis. YY1 may be considered as a metastasis risk factor in WT.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Expresión Génica
/
Factor de Transcripción YY1
/
Neoplasias Renales
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Idioma:
En
Revista:
Future Oncol
Año:
2019
Tipo del documento:
Article
País de afiliación:
México