The history of the two-signal model of lymphocyte activation: A personal perspective.
Scand J Immunol
; 89(6): e12762, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30825214
ABSTRACT
The first ideas leading to The Two-Signal Model of lymphocyte activation were published 50 years ago, but the model was not realized in one sitting. I describe the three phases that led to its contemporary formulations. A motivation underlying all these models was to generate a minimal description of what is required for antigen to inactivate and activate mature lymphocytes that, at the same time, accounts for how peripheral tolerance is achieved. I suggest the two signal model has not only provided a substantiated framework for understanding how antigen interacts differently with B cells and CD8 T cells, to result in their inactivation and activation, but its postulates are pertinent to contemporary issues concerning the inactivation and activation of CD4 T cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Activación de Linfocitos
/
Transducción de Señal
/
Linfocitos T CD8-positivos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Scand J Immunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Canadá