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Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.
Hoxhaj, Gerta; Ben-Sahra, Issam; Lockwood, Sophie E; Timson, Rebecca C; Byles, Vanessa; Henning, Graham T; Gao, Peng; Selfors, Laura M; Asara, John M; Manning, Brendan D.
Afiliación
  • Hoxhaj G; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Lockwood SE; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Timson RC; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Byles V; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Henning GT; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Gao P; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
  • Selfors LM; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  • Asara JM; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Manning BD; Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. bmanning@hsph.harvard.edu.
Science ; 363(6431): 1088-1092, 2019 03 08.
Article en En | MEDLINE | ID: mdl-30846598
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Fosfotransferasas (Aceptor de Grupo Alcohol) / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / NADP Límite: Animals / Humans Idioma: En Revista: Science Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Fosfotransferasas (Aceptor de Grupo Alcohol) / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / NADP Límite: Animals / Humans Idioma: En Revista: Science Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos