Cardiomyocyte SMAD4-Dependent TGF-ß Signaling is Essential to Maintain Adult Heart Homeostasis.

Umbarkar, Prachi; Singh, Anand P; Gupte, Manisha; Verma, Vipin K; Galindo, Cristi L; Guo, Yuanjun; Zhang, Qinkun; McNamara, James W; Force, Thomas; Lal, Hind

Cardiomyocyte SMAD4-Dependent TGF-ß Signaling is Essential to Maintain Adult Heart Homeostasis.

Umbarkar, Prachi; Singh, Anand P; Gupte, Manisha; Verma, Vipin K; Galindo, Cristi L; Guo, Yuanjun; Zhang, Qinkun; McNamara, James W; Force, Thomas; Lal, Hind.

Afiliación

Umbarkar P; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Singh AP; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Gupte M; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Verma VK; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Galindo CL; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Guo Y; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Zhang Q; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.
McNamara JW; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Force T; Division of Cardiovascular Health and Disease, Department of Internal Medicine, Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lal H; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

JACC Basic Transl Sci ; 4(1): 41-53, 2019 Feb.

Article en En | MEDLINE | ID: mdl-30847418

Palabras clave

CM, cardiomyocyte; CSA, cross-sectional area; CTL, control; DCM, dilated cardiomyopathy; KO, knockout; LV, left ventricle/ventricular; MAPK, mitogen-activated protein kinase; MCM, MerCreMer; PI3K, phosphoinositide-3 kinase; RNA-Seq, RNA sequencing; SMAD4; TAK1, transforming growth factor betaactivated kinase 1; TAM, tamoxifen; TGF, transforming growth factor; TGF-ß; cMyBP-C, cardiac myosin-binding protein C; cardiomyocyte; cardiomyopathy; fibrosis; heart failure

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