ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies.

Liu, Yaowu; Chen, Sixing; Li, Zilin; Morrison, Alanna C; Boerwinkle, Eric; Lin, Xihong

Liu, Yaowu; Chen, Sixing; Li, Zilin; Morrison, Alanna C; Boerwinkle, Eric; Lin, Xihong.

Afiliación

Liu Y; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Chen S; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Lin X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: xlin@hsph.harvard.edu.

Am J Hum Genet ; 104(3): 410-421, 2019 03 07.

Article en En | MEDLINE | ID: mdl-30849328

Asunto(s)

Algoritmos; Enfermedad/genética; Estudios de Asociación Genética/métodos; Variación Genética; Genoma Humano; Modelos Genéticos; Análisis de Secuencia de ADN/métodos; Simulación por Computador; Interpretación Estadística de Datos; Humanos

Palabras clave

omnibus test; rare-variant analysis; variant set test; whole-genome sequencing

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Variación Genética / Algoritmos / Genoma Humano / Enfermedad / Análisis de Secuencia de ADN / Estudios de Asociación Genética / Modelos Genéticos Límite: Humans Idioma: En Revista: Am J Hum Genet Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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