Regulation of transposable elements by DNA modifications.
Nat Rev Genet
; 20(7): 417-431, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-30867571
ABSTRACT
Maintenance of genome stability requires control over the expression of transposable elements (TEs), whose activity can have substantial deleterious effects on the host. Chemical modification of DNA is a commonly used strategy to achieve this, and it has long been argued that the emergence of 5-methylcytosine (5mC) in many species was driven by the requirement to silence TEs. Potential roles in TE regulation have also been suggested for other DNA modifications, such as N6-methyladenine and oxidation derivatives of 5mC, although the underlying mechanistic relationships are poorly understood. Here, we discuss current evidence implicating DNA modifications and DNA-modifying enzymes in TE regulation across different species.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Elementos Transponibles de ADN
/
5-Metilcitosina
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Epigénesis Genética
/
ADN (Citosina-5-)-Metiltransferasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido