Catalytic asymmetric cycloaddition reactions of enoldiazo compounds.
Org Biomol Chem
; 17(17): 4183-4195, 2019 04 24.
Article
en En
| MEDLINE
| ID: mdl-30924829
ABSTRACT
This review describes catalytic asymmetric cycloaddition reactions of silyl-protected enoldiazo compounds for the construction of highly functionalized carbo- and heterocycles which possess one or more chiral center(s). The enoldiazo compound or its derivative, donor-acceptor cyclopropene, form electrophilic vinylogous metal carbene intermediates that combine stepwise with nucleophilic dipolar reactants to form products from [3 + 1]-, [3 + 2]-, [3 + 3]-, [3 + 4]-, and [3 + 5]-cycloaddition, generally in high yield and with exceptional stereocontrol and regioselectivity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Azo
/
Cobre
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos