Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics.
J Nat Prod
; 82(5): 1372-1376, 2019 05 24.
Article
en En
| MEDLINE
| ID: mdl-30933514
ABSTRACT
In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenantridinas
/
Antiinflamatorios no Esteroideos
/
Alcaloides de Amaryllidaceae
/
Metabolómica
/
Amaryllidaceae
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2019
Tipo del documento:
Article
País de afiliación:
República Checa