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Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress.
Akiyama, Hiroki; Umezawa, Yoshihiro; Ishida, Shinya; Okada, Keigo; Nogami, Ayako; Miura, Osamu.
Afiliación
  • Akiyama H; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Umezawa Y; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ishida S; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Okada K; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Nogami A; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.
  • Miura O; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: miura.hema@tmd.ac.jp.
Cancer Lett ; 453: 84-94, 2019 07 01.
Article en En | MEDLINE | ID: mdl-30946869
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Ubiquitina Tiolesterasa / Tirosina Quinasa 3 Similar a fms Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Lett Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Ubiquitina Tiolesterasa / Tirosina Quinasa 3 Similar a fms Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Lett Año: 2019 Tipo del documento: Article País de afiliación: Japón