CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.

Bloomer, David T; Kitevska-Ilioski, Tanja; Pantaki-Eimany, Delara; Ji, Yanhao; Miles, Mark A; Heras, Begona; Hawkins, Christine J

Bloomer, David T; Kitevska-Ilioski, Tanja; Pantaki-Eimany, Delara; Ji, Yanhao; Miles, Mark A; Heras, Begona; Hawkins, Christine J.

Afiliación

Bloomer DT; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Kitevska-Ilioski T; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Pantaki-Eimany D; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Ji Y; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Miles MA; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Heras B; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia.
Hawkins CJ; Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3086, Australia c.hawkins@latrobe.edu.au.

Biochem J ; 476(9): 1335-1357, 2019 05 07.

Article en En | MEDLINE | ID: mdl-30992316

Asunto(s)

Caspasa 1; Caspasa 8; Virus de la Viruela Vacuna; Proteolisis; Serpinas; Proteínas Virales; Caspasa 1/química; Caspasa 1/genética; Caspasa 1/metabolismo; Caspasa 8/química; Caspasa 8/genética; Caspasa 8/metabolismo; Línea Celular; Virus de la Viruela Vacuna/química; Virus de la Viruela Vacuna/genética; Virus de la Viruela Vacuna/metabolismo; Humanos; Mutagénesis Sitio-Dirigida; Serpinas/química; Serpinas/genética; Serpinas/metabolismo; Proteínas Virales/química; Proteínas Virales/genética; Proteínas Virales/metabolismo

Palabras clave

caspase; poxviruses; serpins

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Virales / Virus de la Viruela Vacuna / Serpinas / Caspasa 1 / Caspasa 8 / Proteolisis Límite: Humans Idioma: En Revista: Biochem J Año: 2019 Tipo del documento: Article País de afiliación: Australia

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