Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result.
Public Health Genomics
; 21(3-4): 154-163, 2018.
Article
en En
| MEDLINE
| ID: mdl-30999302
ABSTRACT
OBJECTIVES:
Little is known about genetic research participants' responses to receiving individual research results (IRR) from cancer genetic research. We examined the immediate and delayed psychological impact of returning a CDKN2A variant result that is associated with increased risk of pancreatic cancer and melanoma.METHODS:
One hundred and thirty-three pancreas research registry enrollees whose samples were tested in a research laboratory for the CDKN2A variant were invited by mail to learn the result by telephone and participate in a study about the disclosure process. Self-rated health, quality of life, and emotional responses were surveyed before and 6 months after disclosure. Genetic testing-specific distress, uncertainty, and positive experiences were assessed 6 months after disclosure.RESULTS:
Eighty individuals agreed to participate; 63 completed the study. Both carriers and noncarriers showed no change over time in self-rated health, quality of life, or anxiety levels. Carriers reported more sadness than noncarriers before and 6 months after disclosure. Both carriers and noncarriers showed more hopefulness 6 months after than before disclosure. Carriers experienced greater test-specific distress and uncertainty than noncarriers, but levels were low. -Conclusions:
Return of IRR in conjunction with cancer prevention counseling led to low levels of test-specific distress and uncertainty among carriers. No other adverse psychological outcomes were observed.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Revelación de la Verdad
/
Pruebas Genéticas
/
Predisposición Genética a la Enfermedad
/
Mutación
Tipo de estudio:
Prognostic_studies
/
Qualitative_research
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Public Health Genomics
Asunto de la revista:
GENETICA MEDICA
/
SAUDE PUBLICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos