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Could Postnatal Age-Related Uridine Diphosphate Glucuronic Acid Be a Rate-Limiting Factor in the Metabolism of Morphine During the First Week of Life?
Liu, Tao; Lewis, Tamorah R; Moore, Jason N; Kraft, Walter K; Gauda, Estelle B; Sartori, David; Moody, David E; Gobburu, Jogarao V S; Ivaturi, Vijay.
Afiliación
  • Liu T; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
  • Lewis TR; Division of Neonatology, Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
  • Moore JN; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Kraft WK; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Gauda EB; Division of Neonatology, Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
  • Sartori D; Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Moody DE; Center for Human Toxicology, University of Utah, Salt Lake City, Utah, USA.
  • Gobburu JVS; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
  • Ivaturi V; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
CPT Pharmacometrics Syst Pharmacol ; 8(7): 469-477, 2019 07.
Article en En | MEDLINE | ID: mdl-31044547
ABSTRACT
Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body weight as physiologically reasonable predictors of morphine's clearance in neonates. By integrating knowledge of bilirubin, morphine, and other drugs metabolized by glucuronidation pathways from previously published studies, we hypothesize that uridine diphosphate glucuronic acid, a postnatal age-dependent sugar, plays an important role in the metabolism of morphine during the first week of life. This finding can be extended to other drugs metabolized by uridine diphosphate glucuronosyltransferase pathways in neonates and thus has important clinical implications for the use of drugs in this population.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Uridina Difosfato Ácido Glucurónico / Glucuronosiltransferasa / Morfina Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Uridina Difosfato Ácido Glucurónico / Glucuronosiltransferasa / Morfina Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos