Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective.
Genet Epidemiol
; 43(6): 609-616, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31045282
ABSTRACT
With the advent of very large scale genome-wide association studies (GWASs), the promise of Mendelian randomization (MR) has begun to be fulfilled. However, whilst GWASs have provided essential information on the single nucleotide polymorphisms (SNPs) associated with modifiable risk factors needed for MR, the availability of large numbers of SNP instruments raises issues of how best to use this information and how to deal with potential problems such as pleiotropy. Here we provide commentary on some of the recent advances in the MR analysis, including an overview of the different genetic architectures that are being uncovered for a variety of modifiable risk factors and how users ought to take that into consideration when designing MR studies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pautas de la Práctica en Medicina
/
Enfermedad
/
Polimorfismo de Nucleótido Simple
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Estudio de Asociación del Genoma Completo
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Análisis de la Aleatorización Mendeliana
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Pleiotropía Genética
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Implementación de Plan de Salud
Tipo de estudio:
Clinical_trials
/
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
/
Sysrev_observational_studies
Límite:
Humans
Idioma:
En
Revista:
Genet Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
GENETICA MEDICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia