Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins.
J Am Chem Soc
; 141(23): 9415-9421, 2019 06 12.
Article
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| MEDLINE
| ID: mdl-31070901
ABSTRACT
We herein report a direct intermolecular anti-Markovnikov hydroazidation method for unactivated olefins, which is promoted by a catalytic amount of bench-stable benziodoxole at ambient temperature. This method facilitates previously difficult, direct addition of hydrazoic acid across a wide variety of unactivated olefins in both complex molecules and unfunctionalized commodity chemicals. It conveniently fills a synthetic chemistry gap of existing olefin hydroazidation procedures, and thereby provides a valuable tool for azido-group labeling in organic synthesis and chemical biology studies.
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MEDLINE
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Revista:
J Am Chem Soc
Año:
2019
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Article
País de afiliación:
Estados Unidos