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Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes.
Ma, Yong; Dela Cruz-Chuh, Josefa; Khojasteh, S Cyrus; Dragovich, Peter S; Pillow, Thomas H; Zhang, Donglu.
Afiliación
  • Ma Y; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California yongma87@gmail.com.
  • Dela Cruz-Chuh J; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California.
  • Khojasteh SC; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California.
  • Dragovich PS; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California.
  • Pillow TH; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California.
  • Zhang D; Drug Metabolism and Disposition (Y.M., S.C.K., D.Z.), Biochemical and Cellular Pharmacology (J.D.C.-C.), and Discovery Chemistry (P.S.D., T.H.P.), Genentech, South San Francisco, California zhang.donglu@gene.com.
Drug Metab Dispos ; 47(8): 884-889, 2019 08.
Article en En | MEDLINE | ID: mdl-31072822
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inmunoconjugados / Lisosomas / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inmunoconjugados / Lisosomas / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article