Role of the Hippo Pathway in Fibrosis and Cancer.
Cells
; 8(5)2019 05 16.
Article
en En
| MEDLINE
| ID: mdl-31100975
ABSTRACT
The Hippo pathway is the key player in various signaling processes, including organ development and maintenance of tissue homeostasis. This pathway comprises a core kinases module and transcriptional activation module, representing a highly conserved mechanism from Drosophila to vertebrates. The central MST1/2-LATS1/2 kinase cascade in this pathway negatively regulates YAP/TAZ transcription co-activators in a phosphorylation-dependent manner. Nuclear YAP/TAZ bind to transcription factors to stimulate gene expression, contributing to the regenerative potential and regulation of cell growth and death. Recent studies have also highlighted the potential role of Hippo pathway dysfunctions in the pathology of several diseases. Here, we review the functional characteristics of the Hippo pathway in organ fibrosis and tumorigenesis, and discuss its potential as new therapeutic targets.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Proteínas Adaptadoras Transductoras de Señales
/
Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cells
Año:
2019
Tipo del documento:
Article