The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by BDNF and KIBRA Polymorphisms.
J Cogn Neurosci
; 31(9): 1422-1429, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31112471
ABSTRACT
Episodic memory is a polygenic trait influenced by different molecular mechanisms. We used PET and a candidate gene approach to investigate how individual differences at the molecular level translate into between-person differences in episodic memory performance of elderly persons. Specifically, we examined the interactive effects between hippocampal dopamine D2 receptor (D2DR) availability and candidate genes relevant for hippocampus-related memory functioning. We show that the positive effects of high D2DR availability in the hippocampus on episodic memory are confined to carriers of advantageous genotypes of the brain-derived neurotrophic factor (BDNF, rs6265) and the kidney and brain expressed protein (KIBRA, rs17070145) polymorphisms. By contrast, these polymorphisms did not modulate the positive relationship between caudate D2DR availability and episodic memory.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Dopamina D2
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Factor Neurotrófico Derivado del Encéfalo
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Péptidos y Proteínas de Señalización Intracelular
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Memoria Episódica
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Hipocampo
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Cogn Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2019
Tipo del documento:
Article