Rapid analytical method of 90Sr in urine sample: Rapid separation of Sr by phosphate co-precipitation and extraction chromatography, followed by determination by triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS/MS).
Appl Radiat Isot
; 150: 103-109, 2019 Aug.
Article
en En
| MEDLINE
| ID: mdl-31128496
ABSTRACT
A rapid analytical method for determining 90Sr in urine samples (1-2â¯L) was developed to assess the internal exposure of workers in a radiological emergency. Strontium in a urine sample was rapidly separated by phosphate co-precipitation, followed by extraction chromatography, and the 90Sr activity was determined by triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS/MS). Measurement in the MS/MS mode with an O2 reaction gas flow rate 1â¯mLâ¯min-1 showed no tailing of 88Sr at m/zâ¯=â¯90 up to 50â¯mgâ¯L-1 Sr. The interferences of Ge, Se and Zr at m/zâ¯=â¯90 were successfully removed by phosphate co-precipitation, followed by extraction chromatography with a tandem column of Pre-filter, TRU and Sr resin. This analytical method was validated by the results of the analyses of synthetic urine samples (1.2-1.6â¯L) containing a known amount of 90Sr along with 1â¯mg of each of Ge, Se, Sr and Zr. The turnaround time for Sr purification from the urine sample and the 90Sr measurement by ICP-MS/MS was about 10â¯h. The detection limit of 90Sr was approximately 1 Bq per urine sample, which was lower than 15 Bq per urine after a day of intake giving 5â¯mSv of unplanned exposure of worker limited by Nuclear Regulation Authority of Japan.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Radioisótopos de Estroncio
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Appl Radiat Isot
Asunto de la revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Año:
2019
Tipo del documento:
Article