Specific keratinase derived designer peptides potently inhibit A<i>ß</i> aggregation resulting in reduced neuronal toxicity and apoptosis.

Rajput, Rinky; G L, Balasubramani; Srivastava, Ankit; Wahi, Divya; Shrivastava, Nidhi; Kundu, Bishwajit; Grover, Abhinav

Specific keratinase derived designer peptides potently inhibit Aß aggregation resulting in reduced neuronal toxicity and apoptosis.

Rajput, Rinky; G L, Balasubramani; Srivastava, Ankit; Wahi, Divya; Shrivastava, Nidhi; Kundu, Bishwajit; Grover, Abhinav.

Afiliación

Rajput R; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
G L B; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Srivastava A; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi 110016, India.
Wahi D; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Shrivastava N; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Kundu B; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi 110016, India bkundu@bioschool.iitd.ac.in abhinavgr@gmail.com agrover@jnu.ac.in.
Grover A; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India bkundu@bioschool.iitd.ac.in abhinavgr@gmail.com agrover@jnu.ac.in.

Biochem J ; 476(12): 1817-1841, 2019 06 28.

Article en En | MEDLINE | ID: mdl-31138770

Asunto(s)

Péptidos beta-Amiloides; Apoptosis; Bacillus licheniformis/enzimología; Proteínas Bacterianas/química; Simulación del Acoplamiento Molecular; Simulación de Dinámica Molecular; Neuronas/metabolismo; Fragmentos de Péptidos; Péptido Hidrolasas/química; Agregado de Proteínas; Péptidos beta-Amiloides/química; Péptidos beta-Amiloides/metabolismo; Línea Celular Tumoral; Humanos; Neuronas/patología; Fragmentos de Péptidos/química; Fragmentos de Péptidos/metabolismo

Palabras clave

Alzheimer disease; aggregation; amyloid-beta; neuroblastoma; peptides; toxicity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptido Hidrolasas / Proteínas Bacterianas / Péptidos beta-Amiloides / Apoptosis / Simulación de Dinámica Molecular / Simulación del Acoplamiento Molecular / Agregado de Proteínas / Bacillus licheniformis / Neuronas Límite: Humans Idioma: En Revista: Biochem J Año: 2019 Tipo del documento: Article País de afiliación: India

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