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Human leukocyte antigen associations in postural tachycardia syndrome.
Shin, Yong-Won; Moon, Jangsup; Kim, Tae-Joon; Kim, Do-Yong; Chang, Hyeyeon; Jun, Jin-Sun; Lee, Soon-Tae; Jung, Keun-Hwa; Park, Kyung-Il; Jung, Ki-Young; Kim, Manho; Lee, Sang Kun; Chu, Kon.
Afiliación
  • Shin YW; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Moon J; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Kim TJ; Department of Neurosurgery Seoul National University Hospital Seoul South Korea.
  • Kim DY; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Chang H; Department of Neurology Ajou University School of Medicine Suwon South Korea.
  • Jun JS; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Lee ST; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Jung KH; Department of Neurosurgery Seoul National University Hospital Seoul South Korea.
  • Park KI; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Jung KY; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Kim M; Department of Neurology Seoul National University Hospital Healthcare System Gangnam Center Seoul South Korea.
  • Lee SK; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
  • Chu K; Department of Neurology Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital Seoul South Korea.
Ann Clin Transl Neurol ; 6(5): 962-967, 2019 May.
Article en En | MEDLINE | ID: mdl-31139694
ABSTRACT
Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near-syncope while standing (prominent POTS; n = 17). DQB1*0609 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [OR] 8.7, 95% confidence interval [CI] 3.1-24.3, corrected P = 3.2 × 10-4) and epilepsy controls (8%; OR 7.9, 95% CI 2.7-23.5, corrected P = 3.2 × 10-4). Six (35.3%) carried the A*3303-B*5801-C*0302-DRB1*1302-DQB1*0609 haplotype. The results signify an autoimmune etiology in prominent POTS.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de Taquicardia Postural Ortostática / Antígenos HLA Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Ann Clin Transl Neurol Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de Taquicardia Postural Ortostática / Antígenos HLA Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Ann Clin Transl Neurol Año: 2019 Tipo del documento: Article