Hidradenitis Suppurativa: Comprehensive Review of Predisposing Genetic Mutations and Changes.
J Cutan Med Surg
; 23(5): 519-527, 2019.
Article
en En
| MEDLINE
| ID: mdl-31167568
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. A genetic component in the pathogenesis is highly likely considering that ~30% to 40% of patients with HS report a family history of the disease. The genetic mutations related to HS that have been reported to date suggest HS can be inherited as a monogenic trait because of a defect in either the Notch signaling pathway or inflammasome function, or as a polygenic disorder resulting from defects in genes regulating epidermal proliferation, ceramide production, or in immune system function. This review provides a summary of genetic mutations reported in patients diagnosed with HS and discusses the mechanisms by which these genes are involved in its pathogenesis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hidradenitis Supurativa
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Receptores Notch
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Secretasas de la Proteína Precursora del Amiloide
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Inflamación
Límite:
Humans
Idioma:
En
Revista:
J Cutan Med Surg
Asunto de la revista:
DERMATOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Canadá