Targeting Tubulin-colchicine Site for Cancer Therapy: Inhibitors, Antibody- Drug Conjugates and Degradation Agents.

Duan, Yongtao; Liu, Wei; Tian, Liang; Mao, Yanna; Song, Chuanjun

Duan, Yongtao; Liu, Wei; Tian, Liang; Mao, Yanna; Song, Chuanjun.

Afiliación

Duan Y; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Liu W; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Tian L; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Mao Y; Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Song C; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, China.

Curr Top Med Chem ; 19(15): 1289-1304, 2019.

Article en En | MEDLINE | ID: mdl-31210108

Asunto(s)

Antineoplásicos/farmacología; Colchicina/farmacología; Inmunoconjugados/farmacología; Neoplasias/tratamiento farmacológico; Moduladores de Tubulina/farmacología; Tubulina (Proteína)/metabolismo; Animales; Antineoplásicos/química; Antineoplásicos/metabolismo; Sitios de Unión/efectos de los fármacos; Colchicina/química; Colchicina/metabolismo; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Inmunoconjugados/química; Inmunoconjugados/metabolismo; Mitosis/efectos de los fármacos; Neoplasias/metabolismo; Neoplasias/patología; Tubulina (Proteína)/química; Moduladores de Tubulina/química; Moduladores de Tubulina/metabolismo

Palabras clave

Antibody-drug conjugates; Antimitotic; Antitumour; Degraders; Inhibitors; Microtubules; Tubulin-colchicine binding site.

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Colchicina / Inmunoconjugados / Moduladores de Tubulina / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China

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