The Hemostatic Conundrum of Thrombotic Thrombocytopenic Purpura: a Case Report.
Clin Lab
; 65(6)2019 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-31232040
ABSTRACT
BACKGROUND:
In thrombotic thrombocytopenic purpura (TTP), von Willebrand factor (VWF)-platelet rich thrombi form in the microvasculature with ischemia in vital organs. The pathogenesis relates to deficiency of the VWF cleaving protease, ADAMTS-13.METHODS:
A case study of a 58-year-old female with previously undiagnosed HIV (human immunodeficiency virus) infection, left hemiparesis, and soft tissue hemorrhages.RESULTS:
Investigations revealed microangiopathic hemolytic anemia and a left basal ganglia infarct on magnetic resonance imaging (MRI). A diagnosis of acquired, HIV-related TTP was made and therapeutic plasma exchange and antiretroviral therapy were initiated.CONCLUSIONS:
The combined thrombotic and hemorrhagic manifestations of TTP pose therapeutic challenges.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Intercambio Plasmático
/
Púrpura Trombocitopénica Trombótica
/
Infecciones por VIH
/
Antirretrovirales
/
Hemostasis
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Lab
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2019
Tipo del documento:
Article