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Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.
Wang, Sinan; Korenchan, David E; Perez, Paola M; Taglang, Céline; Hayes, Thomas R; Sriram, Renuka; Bok, Robert; Hong, Andrew S; Wu, Yunkou; Li, Henry; Wang, Zhen; Kurhanewicz, John; Wilson, David M; Flavell, Robert R.
Afiliación
  • Wang S; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Korenchan DE; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Perez PM; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Taglang C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Hayes TR; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Sriram R; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Bok R; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Hong AS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Wu Y; Department of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA.
  • Li H; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Wang Z; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Kurhanewicz J; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
  • Wilson DM; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94107, USA.
  • Flavell RR; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA (USA, 94107, USA.
Chemistry ; 25(51): 11842-11846, 2019 Sep 12.
Article en En | MEDLINE | ID: mdl-31338914
ABSTRACT
Alterations in Zn2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn2+ is an area of active investigation. Herein, enriched [1-13 C]cysteine and [1-13 C2 ]iminodiacetic acid were developed as Zn2+ -specific imaging probes using hyperpolarized 13 C magnetic resonance spectroscopy. [1-13 C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13 C chemical shift, resonance linewidth, or T1 .
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos