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Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli.
Chen, Yong-Hong; He, Jiang-Bo; Bai, Xue; Li, Xiao-Nian; Lu, Lan-Feng; Liu, Yan-Chun; Zhang, Ke-Qin; Li, Sheng-Hong; Niu, Xue-Mei.
Afiliación
  • Chen YH; State Key Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences , Yunnan University , Kunming 650091 , P.R. China.
  • He JB; State Key Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences , Yunnan University , Kunming 650091 , P.R. China.
  • Bai X; Kunming Key Laboratory of Respiratory Disease , Kunming University , Kunming 650214 , P. R. China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
  • Lu LF; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
  • Liu YC; State Key Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences , Yunnan University , Kunming 650091 , P.R. China.
  • Zhang KQ; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
  • Li SH; State Key Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences , Yunnan University , Kunming 650091 , P.R. China.
  • Niu XM; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
Org Lett ; 21(16): 6499-6503, 2019 08 16.
Article en En | MEDLINE | ID: mdl-31343888
ABSTRACT
Here we provide an unprecedented biofactory where fluorescent dye-like complex xanthenes could be produced in an engineered Escherichia coli. Feeding the strain with toluquinol or hydroquinones resulted in production of novel "unnatural" natural products including four arthrocolins embedded with indolyltriphenyl quaternary carbons. Arthrocolins A-C potently inhibited various human cancer cell lines including paclitaxel-resistant cell line A549/Taxol and methicillin-resistant Staphylococcus aureus and immensely restored the sensitivity of intractable fluconazole-resistant human pathogen Candida albicans to fluconazole.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Escherichia coli / Antibacterianos / Antifúngicos / Antineoplásicos Límite: Humans Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Escherichia coli / Antibacterianos / Antifúngicos / Antineoplásicos Límite: Humans Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article